In a study on diffuse large B cell lymphoma cell lines, the concomitant treatment with bendamustine and vorinostat showed enhanced histone acetylation and double strand DNA breaks resulting in an additive to synergistic cytotoxic effect in both ABC- and GCB-type DLBCL cells independent of p53 mutation status [29]. Here, TP53 is linked to diffuse large B-cell lymphoma.