VEGFC and breast cancer: However, a recent meta-analysis that included 21 studies and 2828 patients with breast cancer reported HRs of 1.87 (95% CI 1.25–2.79, p = 0.001) for RFS and 1.96 (95% CI 1.15–3.31, p = 0.001) for OS for patients with high tumor VEGF-C expression [5].