Thus, some copy number aberrations involving one or multiple genes that affect a significant fraction of the tumors, (e.g. CNA associated with either gains of chromosome 7 and/or amplification of the epidermal growth factor receptor (EGFR) gene [18], and losses of DNA sequences in chromosome 10 [19], together with other less frequent alterations involving DNA sequences in chromosomes 12q13-15 [25], 4q and 1q [26], have all been associated with the outcome of GBM patients. Here, EGFR is linked to glioblastoma.