To investigate Nup153 potential contribution to the biology of prostate cancer two cellular models were adopted: human immortalized cell lines derived from freshly explanted prostate tumors obtained from patients with diagnosis of clinically localized disease and selected for the absence of hormonal neoadjuvant treatment before surgery [16] and the metastatic prostate cancer cell line LNCaP. This evidence concerns the gene NUP153 and Familial prostate cancer.