The effect of small numbers can be demonstrated in patients with EZH2 mutations, since this mutation had a dismal influence in the MDS INT2/High subgroup (n = 4; HR 8.55; p = 0.001), while the influence of the same mutation was favorable in AML patients (n = 4; HR 0.09; p = 0.022). The gene discussed is EZH2; the disease is acute myeloid leukemia.