Multivariable analysis for survival was conducted taking into account the following variables with a p-value of < 0.1 in univariable analysis: TP53, IDH1, FLT3-ITD, KMT2A-PTD, complex karyotype, anemia (Hb 8–10 g/dl), thrombocytopenia (platelets <50.000/μl), AML vs. MDS (FAB), cytogenetic risk group (IPSS), primary vs. secondary MDS. The gene discussed is TP53; the disease is myelodysplastic syndrome.