In patients with only HCC, ISG20 levels were positively correlated with liver function parameters including AST, ALT, total and direct bilirubin levels (Pearson’s r = 0.39, 0.25, 0.24, and 0.23; P<0.0001, =0.028, 0.033 and 0.04, respectively), and negatively correlated with albumin levels (Pearson’s r = -0.29; P=0.009) (Figure 6). Here, ISG20 is linked to hepatocellular carcinoma.