AFP and laryngotracheoesophageal cleft: In LC patients, ISG20 levels were positively correlated with AFP levels (Pearson’s r = 0.24, P=0.039) and significantly higher in LC patients with AFP levels >25 IU/L compared to those with ≤25 IU/L (25.7 ng/ml vs. 13.6 ng/ml, P=0.046) (Figure 5C and 5D).