In all HCC patients (patients with only HCC and those with LC plus HCC), we observed a strong correlation of ISG20 levels with AST, ALT, total and direct bilirubin levels (Pearson’s r = 0.43, 0.35, 0.34, 0.3; P<0.0001, respectively). The gene discussed is ISG20; the disease is laryngotracheoesophageal cleft.