In patients with LC plus HCC, ISG20 levels were strongly and positively correlated with AST, ALT, total and direct bilirubin levels (Pearson’s r = 0.46, 0.38, 0.33, and 0.32; P<0.0001, P = 0.003, 0.002 and 0.004, respectively) (Figure 7). Here, ISG20 is linked to hepatocellular carcinoma.