ZEB2 and cancer: However, our results do show that whereas depletion of ZEB1 using siRNAs resulted in de-repression of E-cadherin, this was not the case when ZEB2 was depleted using siRNAs, indicating that ZEB2 does not repress expression of E-cadherin., Recently published ZEB2 chip-Seq data, using human cancer cell lines, indicated that the CDH1 gene (E-cadherin) was not a target of ZEB2, it was not enriched by ChIP and furthermore E-cadherin expression was not increased by depletion of ZEB2, thus reinforcing our conclusions [51].