TFAP2B and Holt-Oram syndrome: We did not identify any genes responsible for “hear-hand” syndromes or syndromic conditions with overlapping cardiopathology, limb skeletal manifestation or malformed breast, including TBX5 (Holt-Oram syndrome), LMNA (Slovenian type of heart–hand syndrome), TFAP2B (Char syndrome), TP63 [Limb-mammary syndrome (MIM 603543), ADULT syndrome (MIM 103285)].