CNR1 and Anxiety: By genotyping 706 individuals for the 5′-HTTLPR in the SLC6A4 and four SNPs in CNR1, Lazary et al. (2009) showed that the risk of anxiety was 4.6-fold greater in individuals with genotypes G/G for rs2180619 and S/S for 5-HTTLPR compared with other genotypes.