Moreover, CAFs shows a direct function on the orchestration of TME, inducing preferentially T cell apoptosis and Tregs; in fact the production of IL-6, CXCL8 are responsible for tumor-associated macrophage (TAM) polarization toward M2 macrophage polarization and functions during the differentiation of circulating monocytes to TAMs (16–19) while TGF-β induce the recruitment of macrophages at the tumor site, promoting the effective tumor evasion of the host immune system (20, 21). The gene discussed is TGFB1; the disease is neoplasm.