CXCL8 and neoplasm: TAMs play an important role for lymphangiogenesis through the release of VEGF-C and VEGF-D via VEGFR3, and neo angiogenesis by VEGF, TNF-α, CXCL8, PDGF-β, MMP2, MMP7, and MMP9, both of mechanism are critical steps for tumor growth, invasion, and metastasis (41).