TGFB1 and neoplasm: The dual role of Vδ2 T cells against tumor cells, either antitumoral or protumoral, could be related to the plasticity of γδ T cells to differentiate into different functional subsets under precise polarizing conditions; thus, Vδ2 T cells may display Th1-, Th2- (62), Th9- (63), Th17- (64), or Treg-like (65) profiles and they can produce several immunosuppressive cytokines as TGF-β and IL-10.