We first analyzed secretomes obtained from cancer stem cells (CSC) and CAF of non-melanoma skin cancer patients, and found that the secretome of SCC patients contains cytokines (IL-6, IL-1β, IL-23, and TGF-β) capable of polarizing the differentiation of γδ17 T cells (78, 79), confirming the transition from IFN-γ-producing to IL-17-producing γδ T cells in the TME, during tumor progression observed in these patients. This evidence concerns the gene IL6 and neoplasm.