In CAIX-negative cases, there was little γδTc infiltration; however, when γδTc were quantified in CAIX-positive versus CAIX-negative areas of breast tumors, γδTc frequency was greater in hypoxic regions, significantly so in three cases in particular (Figure 1E, cases 13, 14, and 17, P < 0.0001). The gene discussed is CA9; the disease is breast neoplasm.