In one study, γδTc TIL isolated from a breast tumor were expanded in high levels of IL-2 for several weeks prior to immunosuppression assays and proved to inhibit dendritic cell maturation and CD8+ T cell cytotoxicity (56); however, given the known functional plasticity of γδTc, such assays conducted on ex vivo expanded cells removed from the TME cannot inform the function of γδTc in situ. This evidence concerns the gene CD8A and breast neoplasm.