While we assume that soluble MICA may bind NKG2D and block or downregulate this receptor to prevent γδTc recognition of breast cancer targets, a recent report suggests that, in mice, soluble NKG2D might activate NK cells and aid in tumor eradication, but this anti-tumor effect has yet to be shown in humans or with γδTc (60). The gene discussed is KLRK1; the disease is breast cancer.