For example, a direct cross talk between Smad3 and STAT3 is bridged by p300 in hepatoma cells (72), a synergistic action of LIF-induced-Smad1 and BMP2-induced-STAT3 is bridged by p300 in neural cells (73), and Smad2/3 and STAT3 cooperatively interact in Th17 cell differentiation (74). The gene discussed is SMAD3; the disease is hepatocellular carcinoma.