On the contrary, the MRL/lpr mice treated with pCAGGS-Tgfb3 did not exhibit a decrease in the number of CD4+ T cells and B220+ B cells (Figures S3C,D in Supplementary Material), although B cells and T cells play central roles in the pathogenesis of lupus phenotypes in MRL/lpr mice (44–46). This evidence concerns the gene CD4 and systemic lupus erythematosus.