Importantly, treatment with both pCAGGS-Tgfb3 and pCAGGS-Il10 suppressed autoantibody productions in a murine lupus model induced with TLR7 agonist, imiquimod (26) (Figure 3A; Figure S3A in Supplementary Material). The gene discussed is TGFB3; the disease is systemic lupus erythematosus.