TDO2 and stroke disorder: Several studies reported an increase activation of both tryptophan-2, 3-Dioxygenase (TDO)/IDO and also kynurenine aminotransferases, which leaded to an augmentation of 3-HK, QUIN, L-Kyn, and KYNA production, which finally induced ROS generation and alterations in glutamatergic neurotransmission in stroke patients (160).