PML and acute myeloid leukemia: Acute promyelocytic leukemiaAPL is a subtype of acute myeloid leukemia (AML) characterized with distinct molecular and clinical features, and majority of cases characterized by the fusion between retinoic acid receptor alpha gene (RARα) on chromosome 17 and the partner gene promyelocytic leukemia (PML) on chromosome 15 as a result of reciprocal translocation t(15;17)(q24;q21), leading to the expression of a novel PML-RARα oncoprotein (18).