Correlations between T1DM and other autoimmune diseases has been weak, but there is genetic evidence that genes of the immunoregulatory pathways, such as Foxp3, IL-2 and its receptors, CD28, and TGFβ1 and its receptors may play critical roles in the onset of T1DM. Here, TGFB1 is linked to type 1 diabetes mellitus.