Neutrophils themselves produce a number of cytokines such as TNFα, IL-12 or, again, IL-8 (CXCL8), in addition to the aforementioned IL-17, which may add to the overall pro-inflammatory environment, recruitment of additional leukocytes, and NET production (137), creating a vicious circle that can be efficiently intercepted by modern therapies directed against the key cytokines IL-23 and IL-17 as well as TNFα in psoriasis (Figure 4C). This evidence concerns the gene TNF and psoriasis.