Among the different results of this study, it worth to highlight: (I) The DDX20 C/T SNP (rs197412) affected miRNA biogenesis and this SNP C allele was associated with an increased risk of AIDS-NHL; (II) The T allele of miR-196a2 C/T SNP (rs11614913) (located at miR-196a2 coding region) was linked to a decreased risk of central nervous system (CNS) AIDS-NHL; (III) The T allele of HIF1A-AS2 C/T SNP (rs2057482) was associated with an increased risk of systemic AIDS-NHL, and (IV) the same allele decreased the risk of CNS AIDS-NHL (104). Here, HIF1A is linked to AIDS.