The are some evidence of the role of B-cell in CDV in humans: splenectomized patients has increased risk of death owing a myocardial infarction, some genes related with B-cells have been related with CDV events and IgM-mediated LDL have an inverse association with atherosclerosis (25, 30, 31, 43–45). The gene discussed is CD40LG; the disease is atherosclerosis.