Nevertheless, in acute T. cruzi-infected C57BL/6 mice, its systemic and adipose tissue derived-expression is sharply diminished, suggesting that its loss may fuel thymic atrophy (97) However, and unlike what happens in models of experimental endotoxemia (100), leptin replacement during the acute infection, while attenuating GC release, fails in reversing thymic atrophy (97). Here, LEP is linked to thymus atrophy.