Moreover, at the genus level, the APP/PS1 transgenic mice exhibited an enrichment of some potential anti-AD microbes, such as Lactobacillus, Akkermansia, Bacteroides, Adlercreutzia, and Desulfovibrio, and reduced levels of other potential anti-AD microbes, such as Ruminococcus, Bifidobacterium, Blautia, Oscillospira, Coprococcus, Sutterella, and Clostridium, compared with the normal group (Figure 4A). Here, APP is linked to Alzheimer disease.