Taking into account that IP-10/CXCL10 is associated with a Th1 response, and eotaxin-2/CCL24 (as eotaxin-1/CCL11) is related to a Th2 response, this result suggested an imbalance of Th1/Th2 cytokines toward a Th1 profile in bipolar disorder (30). This evidence concerns the gene CCL11 and bipolar disorder.