Other studies have found that casticin improves liver fibrosis by suppressing TGF-β and the Smad pathway, and it may also protect against the inflammatory response in LPS-induced acute lung injury in mice by inhibiting the NF-κB and NLRP3 pathways (Wang et al., 2016; Zhou et al., 2017). Here, NFKB1 is linked to Hepatic fibrosis.