SOD1 and amyotrophic lateral sclerosis: Interestingly, a recent meta-analysis of SOD1-G93A ALS mouse data showed that while some treatments, like those targeting oxidative stress, could decrease functional decline by an average of 59.6%, only a 10% average difference in survival was noted; this also suggests that muscle function, while important to quality of life and a key target of ALS disease, is likely not the primary, direct contributor to survival (Bond et al., 2018).