CHD2 and cancer: In addition to de novo germline variants, somatic variants in many of these remodelers are associated with various types of cancer, including prostate cancer (CHD1), chronic lymphocytic leukemia (CHD2), endometrial cancer (CHD4) and neuroblastoma (CHD5/CHD9, Thompson et al., 2003; Liu W. et al., 2012; Rodríguez et al., 2015; Lasorsa et al., 2016).