Although DNA hypo-methylation in vitro and higher levels of DNA methylation in vivo as epigenetic alterations in AD have been reported (Sanchez-Mut and Graff, 2015), roles of target genes of PAX3 and PAX7 such as Cdc20 and Id3 have not been researched in neither AD nor MDD (Diao et al., 2012). The gene discussed is PAX7; the disease is major depressive disorder.