Over expression of several genetically identified mutated growth factors (e.g., MYC, PI3K, MAPK, erythropoietin receptor-B cell factor-1-EBCR1 or BCR, Notch1, Notch2, FBXW7 and polymerases) or perhaps low level histamine [e.g., independent from MCs activation (‘leaky’ MCs), or in the absence of functional MCs] that trigger oncogenesis in childhood cancers are characteristics of adult cancers [5, 39, 73–76, 89]. The gene discussed is NOTCH1; the disease is cancer.