Review of related data suggests that oxidative stress and aging (senescence) lead to development of tolerance (e.g., expression of IRAK-M, IL-1dRs, TNFdRs, PGE2) and/or ‘intolerance’ (e.g., increased allergic responses to innocuous or self-components) as contributing factors in skewed response network of effective immunity and induction of autoimmune or neurodegenerative diseases or cancer [5, 7, 36–40, 67, 75, 157–166, 218]. Here, IRAK3 is linked to cancer.