Detailed analyses of related data suggest that cancer oncogenes mutations and growth dysregulation, along with associated enhanced expression of PI3K/Akt and altered balance in c-MYC, HIF or p53 pathways, adversely influence transport and metabolism of glucose, amino acids, ions or water channels (aquaporins) of the surrounding normal tissues that impair extra- and intracellular components (e.g., mitochondria, ER, nucleus). This evidence concerns the gene TP53 and cancer.