Related data on obesity show low-grade inflammation and impairment of insulin receptor signaling and insulin resistance are mediated through the complex and interdependent stress kinases [e.g., p38, mitogen-activated protein kinase (MAPK), c-Jun NH2-terminal kinase (inhibitor of NF-kB kinase-β-IKKβ), AMP-activated protein kinase, protein kinase C, Rho-associated coiled-coil containing protein kinase, RNA-activated protein kinase] to phosphorylate the key regulators of glucose homeostasis in various tissues. The gene discussed is INSR; the disease is Insulin resistance.