IRAK3 and neoplasm: Tumor-derived factors such as acidic gangliosides (sialic acid-containing glycosphingolipids), hyaluronan, glycosaminoglycan or C-type lectin that are generated in the extracellular matrix or plasma membrane of different cell types (e.g., chondriocytes, MΦs or DCs) are capable of stimulating expression of IRAK-M that would inhibit danger signals (e.g., TLRs) in monocytes leading to immune suppression.