Whether expression of intrinsic factors [e.g., constituent or induced receptors (PM1K, PM2K), mTOR/PI3K, IRAK-M, IL-1dRs, CAMs, PGE2, indolamine 2,3-dioxygenase, NFkB] that are anabolic during wound healing or induction of cancer growth act differently from those anti-inflammatory agents (e.g., aspirin) that are reported to improve or lower cancer entropy are among important knowledge gaps that deserve further study. Here, IRAK3 is linked to cancer.