The mechanisms of action of GSK-3 are additional examples of biorhythms or Yin–Yang of immunity, playing as tumor suppressor or tumor promoter and involving pathways of PI3K/PTEN/Akt/mTOR, Ras/Raf/MEK/ERK [5, 39, 98–101, 127, 128]. Here, PTEN is linked to neoplasm.