In multivariate analysis (Table 3), the Cox proportional hazard model identified that patients with low LC3 expression in both HCC and ANT tissues had the highest risk of HCC recurrence (−/−; HR: 5.02; 95% CI: 1.372–18.83), followed by those low LC3 expression in HCC tissues only (−/+; HR: 3.19; 95% CI: 1.13–12.09), those low LC3 expression in ANT tissues only (+/−; HR: 1.66; 95% CI: 1.051–2.620) and those with the presence of liver cirrhosis (HR: 1.66; 95% CI: 1.049–2.631). Here, MAP1LC3A is linked to hepatocellular carcinoma.