In multivariate analysis, the Cox proportional hazard model identified that patients with low LC3 expression in both the HCC and ANT tissues had the highest risk of HCC recurrence (−/−; hazard ratio [HR]: 6.12; 95% confidence interval [CI]: 2.473–17.53), followed by those low LC3 expression in HCC tissues only (−/+; HR: 4.18; 95% CI: 1.285–13.61), those low LC3 in ANT tissues only (+/−; HR: 1.89; 95% CI: 1.299–2.757), those with macrovascular invasion (HR: 1.63; 95% CI: 1.043–2.492) and those with the presence of liver cirrhosis (HR: 1.59; CI: 1.088–2.326) (Table 3). This evidence concerns the gene MAP1LC3A and cirrhosis of liver.