In multivariate analysis, the Cox proportional hazard analysis identified that patients with low LC3 expression in both HCC and ANT tissues had the highest risk of HCC recurrence (−/−; HR: 6.54; 95% CI: 2.934–15.81), followed by those low LC3 expression in HCC tissues only (−/+; HR: 3.26; 95% CI: 1.034–10.27), those with the presence of macrovascular and microvascular invasion (HR: 2.65; 95% CI: 1.306–5.343 and HR: 2.55; 95% CI: 1.177–5.504, respectively) and those low LC3 expression in ANT tissues only (+/−; HR: 2.09; 95% CI: 1.313–3.321) (Table 3). The gene discussed is MAP1LC3A; the disease is hepatocellular carcinoma.