To test this hypothesis, we first examined markers of eEF2K activity,1 i.e., phosphoryaltion of eEF2 on serine residue 56, in postmortem PD brains in order to establish its relevance to human pathology, and subsequent to the induction of AS pathology in transgenic mouse M83 line expressing PD-associated mutant Ala53Thr (A53T) AS [20, 58]. The gene discussed is EEF2; the disease is Parkinson disease.