Location, [10, 32] extent of resection, [15, 17, 20, 33–35] presence of atypia, [36] brain invasion, [23, 26, 37, 38] high MI, [26, 37–39] high MIB1 labelling, [15, 17, 33, 39] bone involvement, [19, 23, 37] use of adjuvant radiotherapy [9, 40–42] and secondary progression from WHO I tumour. This evidence concerns the gene MIB1 and neoplasm.