Indeed, restoration of memory deficits in 5XFAD and APP/PS1 mouse models of Alzheimer’s disease (AD) have been shown after both acute and chronic administration of DHF (Bollen et al. 2013; Devi and Ohno 2012; Zhang et al. 2014c), while it did not seem to exert this effect when injected chronically in APP23PS45 transgenic mice (Zhou et al. 2015). This evidence concerns the gene APP and Alzheimer disease.