Knowing that, in a rat model of depression, increases in BDNF in the VTA-NAc (Shirayama et al. 2015; Zhang et al. 2015b) induced pro-depressive-like effects (Eisch et al. 2003), the use of partial antagonists as a treatment for diseases related to nervous system dysregulations has been considered. This evidence concerns the gene BDNF and depressive disorder.