CLDN18 and gastric cancer: We noticed that AGS cells have a verified RHOA mutation in its conserved GTPases domain according to COSMIC database (version 81, http://cancer.sanger.ac.uk/cosmic/), while RHOA were considered to be mutually exclusively mutated with CLDN18-ARHGAP26/6 in gastric cancer patients from TCGA, indicating RHOA mutation and CLDN18-ARHGAP26/6 may function with the similar mechanism in gastric tumorigenesis as well as drug response.