The primary cellular origin of IL‐1β in atherosclerosis is unclear, but we have previously shown in coronary atherosclerotic plaques of patients with IHD that IL‐1β is predominantly expressed in relatively large amounts in the endothelium and vasa vasorum.75 We did show robust reductions in IL‐8, RANTES, and MCP‐1 in plasma, although previous animal studies have reported no significant correlation between DHA feeding and these plasma cytokines.76 Most of these studies, however, were small and used fish oil, with little attention given to specific DHA effects. The gene discussed is IL1B; the disease is atherosclerosis.