Notably, inflammation of the endothelium, which is indicated in MS brain microvasculature by up-regulation of the adhesion molecule VCAM-1 [79] and aberrant distribution of TJ proteins occludin, ZO-1 and JAM-A [80, 81] in active lesions is a potent trigger for endothelial cells, in general, to release EVs [41, 43, 82–84]. This evidence concerns the gene OCLN and myeloid sarcoma.