Accumulating evidence suggests that the ALDH2 rs671 polymorphism is associated with the risk of CAD in Asian population [8, 13–16], and the mechanisms may relate to the effect of ALDH2 rs671 polymorphism on hypertension [17–19], dyslipidemia [13, 20, 21], and endothelial asymmetric dimethylarginine (ADMA) levels [9]. The gene discussed is ALDH2; the disease is metabolic syndrome.