INS and Insulin resistance: In this study, the product of dynamic, static and total β cell responsiveness and insulin sensitivity, also called the disposition indices (DId, DIs, and DItotOB) calculated by an oral minimal model [96], showed that metformin (1000–1500 mg twice daily) for 2 weeks caused a significant increase in DId, DIs, and DItotOB, a decreased homeostasis model assessment of insulin resistance (HOMA-IR), and an increased insulin sensitivity, majorly whole-body insulin sensitivity [97].