NFASC and amyotrophic lateral sclerosis: Again, the group difference was significantly different (F2,140 = 23.68, p < 0.0001) with a significant time penalty for maintaining a Nf isoform stoichiometry of 7:3:2 in ALS if compared with an adaptive stoichiometry of 24:2.4:1.6 in ALS (p < 0.0001) or control subjects (p < 0.0001).