Total Nf isoform translation times in control subjects were 24 ± 11 h compared to 51 ± 40 h in patients with ALS and a Nf isoform stoichiometry of 24 : 2.4 : 1.6, which tripled to 148 ± 138 h if a Nf isoform stoichiometry of 7 : 3 : 2 was to be maintained. This evidence concerns the gene NFASC and amyotrophic lateral sclerosis.