SLC12A2 and brain disorder: Second, because to the best of our knowledge, except for bumetanide and furosemide, none of the chemically diverse loop diuretics used here have previously been tested for inhibitory effects on hNKCC1, we wanted to evaluate whether any of these drugs inhibit hNKCC1 with similar or higher potency than bumetanide, but, based on structure, physicochemical properties, and pharmacokinetics may have advantages vs. bumetanide for treatment of brain diseases with abnormal cellular chloride homeostasis.