Whereas a screening of CD133+ cells in tumor microenvironment showed that 1-MT, 1-MT+TL, and 1-MT+DCs-TL were significantly reduced a population of CD133+ cells in the tumor microenvironment in comparison to PBS (1.0%, 0.5%, 0.7%, and 4.6%) respectively (Fig. 3C,D). The gene discussed is PROM1; the disease is neoplasm.