On the other hand, the univariate analysis of OS revealed that an older age (≥65 years), gender (male), tumor location (head), tumor size (≥20 mm), portal vein invasion, perineural invasion, UICC stage, mesenchymal EMT status, and high LOXL2 expression were significant prognostic factors for PC. This evidence concerns the gene LOXL2 and pachyonychia congenita.