Among transcription factors predicted to bind the promoters of these genes and regulate their expression, the candidate master regulatory factor Forkhead Box C1 (Foxc1) was of specific interest, because it was the only candidate factor that appeared in multiple analyses, and the only candidate significantly upregulated in our Ezh2−/− endpoint tumours (Supplementary Figure 3F). The gene discussed is EZH2; the disease is neoplasm.