TREX1 and Aicardi-Goutieres syndrome: In line with this, TREX1, SAMHD1 and ADAR1 have been shown to inhibit the mobility of LINE‐1s (Stetson et al, 2008; Zhao et al, 2013; Orecchini et al, 2017), and RNase H2, mutated in more than half of all known AGS patients (Crow et al, 2015), was suggested to similarly control LINE‐1 retrotransposition (Volkman & Stetson, 2014).