Because TPIS, PGAM1, and PDXK identified in Fig. 3, have also been reported as important glycolysis enzymes altered in schizophrenia (28, 29) and similarities between psychiatric disorders have been reported in recent studies (30, 31), we investigated total expression level of these proteins employing 1D-Western blot analysis (supplemental Fig. S2A). This evidence concerns the gene SPAG1 and psychiatric disorder.