UCHL1, SYUB (beta-synuclein), SYUA (alpha-synuclein), SEPT5, UBE2K, TPIS, MK01 (mitogen-activated protein kinase 1), GNAO (guanine nucleotide-binding protein G(o) subunit alpha), 1433T (14-3-3 protein theta), 1433E (14-3-3 protein epsilon) and KCRB are associated with the onset of neurodegenerative diseases such as AD and PD (51, 57, , , , , –63). Here, SPAG1 is linked to Alzheimer disease.