Since resveratrol, as an antioxidant and antiinflammatory agent is known to have some beneficial effects on the ovary and with the given information above about the AMPK-SIRT1 pathway [27, 36, 37], in this study we hypothesise that combined therapy of resveratrol and metformin might have beneficial effects on PCOS via SIRT1 and AMPK activation. Here, SIRT1 is linked to polycystic ovary syndrome.