METTL14 and acute myeloid leukemia: For instance, Weng and coauthors observed the increase of the expression of m6A methyltransferase METTL14 in healthy HSPCs and acute myeloid leukemia (AML) cells carrying the t(11q23), t(15;17), or t(8;21) mutations, and its downregulation during myeloid differentiation [230].