Real time-PCR was used to validate the expression of selected genes related to the CREB transcription factor: RCHY1, CCL13, LAIR1 (leukocyte-associated immunoglobulin-like receptor 1), TRIM24, CCR2, MYO6, BMS1 and DSP. The results showed that RCHY1, CCL13, LAIR1 and TRIM24 were significantly up-regulated genes and CCR2, MYO6, BMS1 and DSP were significantly down-regulated genes in pediatric patients with epilepsy (see Figure 2 and Figure 3). This evidence concerns the gene CREB1 and epilepsy.