Moreover, our results showed that VPA differentially regulates the gene expression profile in epileptic children during the 6 and 12 months of treatment, principally in one group of genes related with the CREB transcription factor, suggesting the LAIR1-CREB axis as a possible action mechanism of this AED in generalized epilepsy. The gene discussed is LAIR1; the disease is idiopathic generalized epilepsy.