Among the genes that were highly expressed in the epileptic group, we found RCHY1, CCL13, LAIR-1, RPSAP58, IL6R, CCDC14, AFAP1L2, TRIM24, CSMD1, ZNF704, CDK5RAP3, FRAS1, SKA1, CYS1, IL5, LHFP and CPB1. Interestingly, VPA treatment reduced their expression, suggesting that these genes promote epilepsy, since this condition was also diminished as the treatment period progressed. The gene discussed is AFAP1L2; the disease is epilepsy.