In contrast, no evidence of LGP2 cleavage or noticeable decrease was observed during infection with a set of different viruses, including unrelated picornaviruses AiV and EMCV, and other RNA viruses causing swine vesicular disease similar to FMD like SVDV—picornavirus—and VSV—rhabdovirus, suggesting that no evident specific mechanisms targeting LGP2 integrity were exerted by these other viruses. This evidence concerns the gene DHX58 and infection.