We found that CT26 alone (1 × 102 or 1 × 103 living cells) did not result in macroscopic tumors, even at 60 d postinjection; however, CT26 debris generated in vitro by treatment with 5-FU promoted tumor growth of an inoculum as low as 1 × 102 living tumor cells (Fig. 1I). Here, DDX53 is linked to neoplasm.