YY1 is a member of the GLI‐Kruppel family of transcriptional factors, and in recent years, many studies have found that YY1 was abnormal expression in different human tumor tissues and participated in multiple signaling pathways which were associated with tumorigenesis.42, 43 Our clinical data and functional analyses supported that genomic DNA fragment containing the susceptible allele (A) of this particular SNP had a lower binding affinity to transcription factor YY1 and a higher silencing efficacy against TRIM26 than that of the T allele, thereby downregulating TRIM26 expression (Figure 3). The gene discussed is GLI1; the disease is neoplasm.