NFKB2 and breast cancer: For example, silencing of IRF7 pathways can promote immune escape of breast cancer cells, facilitating bone metastasis.50 Interestingly, silencing of TRIM26 was found in our study to be able to attenuate the expression of IFN‐mediated immune genes including IRF7 and NFKB2 (Figure 5, Figure S6).