Both TFSEARCH and FastSNP predict that rs117565607 is probably involved in the transcriptional regulation of TRIM26. TRIM26 is a member of the tripartite motif (TRIM) protein family composed of more than 70 members in human.29 In recent years, the TRIM protein family, such as TRIM3, TRIM16, TRIM28, and TRIM40, have been reported for their roles in cancers.30, 31, 32, 33 However, to date, its role in tumor remains unclear. The gene discussed is TRIM40; the disease is cancer.