Interferons have long been reported to play pleiotropic roles in cancer immunosurveillance and in the broader process of cancer immunoediting.36 Many TRIM genes are IFN inducible and involved in IFN‐mediated immune response.37, 38 To explore whether TRIM26 downregulation could reduce the effects of IFN‐mediated immune response, we used type I IFN to treat NPC cells and PBMCs in which TRIM26 was silenced by siRNA. Here, IFNA1 is linked to nasopharyngeal carcinoma.