APC and Familial adenomatous polyposis: Apc mutation, an early stage of tumour development and the causative mutation in familial adenomatous polyposis, occurs in almost 80% sporadic colon adenomas and CRC in human.22, 23, 24 Therefore, establishing the effects of DCA in a model with an Apc mutation is of great importance in mimicking human intestinal adenoma‐adenocarcinoma sequence carcinogenesis.7, 25 It is appropriate for investigating mechanisms of carcinogenesis and pre‐clinical testing of cancer preventative agents,26, 27, 28 although Apcmin/+ mouse spontaneously develops multiple adenomas mainly in the small intestine.