EGFR and intestinal neoplasm: Our previous studies have already showed that DCA enhanced the multiplicity of intestinal tumours and accelerated intestinal adenoma‐adenocarcinoma sequence in Apcmin/+ mice.7, 16 And recent research provided evidence that DCA induced EGFR/STAT3 signalling to promote gastrointestinal cancer progression.15 In this study, we investigated whether DCA promoted intestinal carcinogenesis through activation of ADAM‐17/EGFR signalling axis.