Epidermal growth factor receptor (EGFR), which plays an important role in tumorigenesis, is overexpressed in many types of cancers, especially in CRC.9, 10 EGFR tyrosine kinase activation leads to the activation of numerous of intracellular signals, which are critical to tumour progression, including cell growth, epithelial‐mesenchymal transition (EMT), metastasis and angiogenesis. This evidence concerns the gene EGFR and neoplasm.