In addition, Endostar down‐regulates miR‐l26 and up‐regulates miR‐221, thereby repressing angiogenesis in human umbilical vein endothelial cells (HUVECs).79 Endostar has the capacity to inhibit the formation of new blood vessels in tumour and normalizes tumour blood vessels, which is also called recombinant human endostatin injection.79 Thus, it is possible to develop specific miRNA‐based therapeutic strategies for treating specific tumour and vascular diseases. The gene discussed is COL18A1; the disease is neoplasm.