ZEB1 and liver dysplastic nodule: Mechanically, loss of miR‐192 expression can promote renal tubulointerstitial fibrosis and decrease estimated GFR in DN in vivo by enhancing TGF‐β‐mediated down‐regulation of E‐cadherin via targeting ZEB1 and ZEB2 in proximal tubular cells (PTCs).220 However, more in‐depth studies are required to investigate the relationship between renal function and miR‐192 levels in renal biopsies, blood and urine in different DN stages.