In addition, let‐7f mimics improve pro‐angiogenic cell (PAC) number, proliferation, migration and network formation and promote angiogenesis in HUVECs exposed to cigarette smoke extracts (CSEs) by inhibiting the levels of TGF‐bR1 (ALK5), SMAD2/3 and plasminogen activator inhibitor type 1 (PAI‐1) both in vitro and in vivo.105 Kong et al106 found that miR‐let‐7e‐5p is down‐regulated in DVT patients and overexpression let‐7e‐5p enhances the ability of homing and thrombus revascularization in rat model of venous thrombosis (VT) via targeting Fas ligand (FASLG). This evidence concerns the gene TGFBR1 and deep vein thrombosis.